Acquired Factor XIII Deficiency in a Patient with Metastatic Lung Cancer

Acquired factor XIII (FXIII) deficiency can result in life-long bleeding tendency and be caused by enhanced consumption, impaired synthesis, or as an immune-mediated process. The latter related with solid neoplasms, through neutralizing non-neutralizing antibodies. relationship between FXIII activity non-small cell lung cancer (NSCLC) is not well established. This case report about a patient NSCLC acquired deficiency. Materials Methods: Clinical records were obtained the electronic process analysis, confidentiality of was always assured. Results Discussion: A 70-year-old male no relevant past medical history recently diagnosed metastatic admitted for priapism. Five days later, he developed disorder, slightly elevated coagulation times normal fibrinogen levels platelets count. level found to decreased (0.24 IU/mL) plasma mixing studies did confirm presence inhibitor. correction standard favour antibody. Despite treatment, haemorrhage control achieved died. Conclusion: clinical describes rare presenting severe haemorrhagic event antibodies subsequent increased clearance.